Yuan Chang Selected Research

Tumor Viral Antigens (Large T Antigen)

12/2020	Merkel Cell Polyomavirus Encodes Circular RNAs (circRNAs) Enabling a Dynamic circRNA/microRNA/mRNA Regulatory Network.
1/2018	Limited detection of human polyomaviruses in Fanconi anemia related squamous cell carcinoma.
10/2017	High truncated-O-glycan score predicts adverse clinical outcome in patients with localized clear-cell renal cell carcinoma after surgery.
12/2015	Merkel cell polyomavirus T antigens promote cell proliferation and inflammatory cytokine gene expression.
4/2015	Large T and small T antigens of Merkel cell polyomavirus.
1/2015	Merkel Cell Polyomavirus Small T Antigen Induces Cancer and Embryonic Merkel Cell Proliferation in a Transgenic Mouse Model.
5/2014	Merkel cell polyomavirus-positive Merkel cell carcinoma requires viral small T-antigen for cell proliferation.
1/2013	Characterization of an early passage Merkel cell polyomavirus-positive Merkel cell carcinoma cell line, MS-1, and its growth in NOD scid gamma mice.
9/2010	Lack of evidence for basal or squamous cell carcinoma infection with Merkel cell polyomavirus in immunocompetent patients with Merkel cell carcinoma.
7/2010	Merkel cell polyomavirus-infected Merkel cell carcinoma cells require expression of viral T antigens.

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Yuan Chang Research Topics

Disease

64	Neoplasms (Cancer) 07/2022 - 11/2002
21	Renal Cell Carcinoma (Grawitz Tumor) 03/2020 - 01/2015
14	Urinary Bladder Neoplasms (Bladder Cancer) 09/2022 - 01/2017
13	Infections 12/2021 - 11/2005
9	Carcinoma (Carcinomatosis) 01/2022 - 09/2009
8	Merkel Cell Carcinoma 04/2015 - 09/2009
7	Carcinogenesis 11/2018 - 09/2009
4	Neoplasm Metastasis (Metastasis) 11/2019 - 08/2015
4	Necrosis 09/2017 - 11/2005
4	Skin Neoplasms (Skin Cancer) 01/2017 - 09/2009
4	Inflammation (Inflammations) 05/2016 - 09/2015
3	Brain Injuries (Brain Injury) 09/2021 - 01/2020
3	Primary Effusion Lymphoma 01/2020 - 12/2005
3	Lymphatic Metastasis 08/2017 - 08/2015
3	Retinoblastoma (Glioblastoma, Retinal) 12/2015 - 10/2008
3	Kaposi Sarcoma (Kaposi's Sarcoma) 06/2014 - 05/2004
2	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 01/2022 - 01/2020
2	Brain Edema (Cerebral Edema) 01/2021 - 01/2020
2	Squamous Cell Carcinoma (Epidermoid Carcinoma) 01/2020 - 09/2010
2	Apnea 01/2019 - 05/2017
2	Hypoxia (Hypoxemia) 01/2019 - 12/2016
2	Breast Neoplasms (Breast Cancer) 02/2018 - 03/2016
2	Colorectal Neoplasms (Colorectal Cancer) 01/2018 - 01/2018
2	Virus Diseases (Viral Diseases) 12/2011 - 11/2002
2	Lymphoma (Lymphomas) 12/2005 - 11/2002
1	Adenocarcinoma 01/2022
1	Lung Neoplasms (Lung Cancer) 01/2022
1	Pemphigus (Pemphigus Vulgaris) 12/2021
1	Ulcerative Colitis 10/2021
1	Status Epilepticus (Complex Partial Status Epilepticus) 01/2021
1	Cognitive Dysfunction 01/2021
1	Tertiary Lymphoid Structures 01/2021

Drug/Important Bio-Agent (IBA)

13	Proteins (Proteins, Gene)FDA Link 01/2022 - 09/2009
13	Oncogene Proteins (Oncogene Protein)IBA 01/2018 - 09/2009
12	Tumor Viral Antigens (Large T Antigen)IBA 12/2020 - 10/2008
9	CytokinesIBA 06/2022 - 11/2002
8	DNA (Deoxyribonucleic Acid)IBA 01/2018 - 09/2009
6	Biomarkers (Surrogate Marker)IBA 09/2022 - 12/2017
4	RNA (Ribonucleic Acid)IBA 12/2020 - 01/2018
4	Circular RNAIBA 12/2020 - 01/2018
4	MicroRNAs (MicroRNA)IBA 12/2018 - 06/2013
4	sialosyl-T antigenIBA 01/2018 - 09/2011
4	Viral DNAIBA 01/2012 - 02/2008
3	Peptides (Polypeptides)IBA 02/2022 - 09/2010
3	LigandsIBA 01/2021 - 03/2016
3	CollagenIBA 01/2018 - 11/2005
3	AntigensIBA 10/2017 - 12/2005
3	Interleukin-6 (Interleukin 6)IBA 12/2015 - 11/2002
2	Neuropilin-1IBA 09/2022 - 12/2021
2	Immune Checkpoint InhibitorsIBA 09/2022 - 01/2022
2	Cisplatin (Platino)FDA LinkGeneric 01/2022 - 01/2018
2	Tyrosine Kinase InhibitorsIBA 01/2022 - 01/2020
2	Glyburide (Glibenclamide)FDA LinkGeneric 01/2021 - 01/2020
2	Nucleic AcidsIBA 11/2020 - 06/2014
2	NivolumabIBA 10/2020 - 01/2020
2	Adenosine Triphosphate (ATP)IBA 01/2020 - 09/2015
2	Therapeutic UsesIBA 01/2020 - 01/2018
2	Messenger RNA (mRNA)IBA 01/2020 - 11/2005
2	Pharmaceutical PreparationsIBA 01/2020 - 05/2012
2	Indicators and Reagents (Reagents)IBA 01/2020 - 04/2016
2	CC ChemokinesIBA 01/2020 - 02/2016
2	Immunoglobulin G (IgG)IBA 01/2020 - 09/2009
2	Long Noncoding RNAIBA 11/2019 - 01/2018
2	Oxygen (Dioxygen)IBA 01/2019 - 05/2017
2	AntibodiesIBA 01/2019 - 09/2009
2	Glutamine (L-Glutamine)FDA Link 01/2019 - 11/2015
2	MucinsIBA 11/2016 - 04/2016
2	Retinoblastoma ProteinIBA 01/2013 - 01/2003
2	SurvivinIBA 01/2013 - 05/2012
2	Connective Tissue Growth FactorIBA 01/2012 - 02/2010
2	Viral ProteinsIBA 12/2011 - 01/2003
2	Viral AntigensIBA 09/2010 - 09/2009
2	Monoclonal AntibodiesIBA 09/2010 - 09/2009
1	Hyaluronoglucosaminidase (Hyaluronidase)FDA Link 01/2022
1	Cetuximab (Erbitux)FDA Link 01/2022
1	ErbB Receptors (EGF Receptor)IBA 01/2022
1	Bevacizumab (Avastin)FDA Link 01/2022
1	osimertinibIBA 01/2022
1	brigatinibIBA 01/2022
1	Recombinant ProteinsIBA 12/2021
1	Rituximab (Mabthera)FDA Link 12/2021
1	Glycoproteins (Glycoprotein)IBA 12/2021
1	Serine Proteases (Serine Protease)IBA 12/2021
1	CXC ChemokinesIBA 01/2021
1	tau Proteins (tau Protein)IBA 01/2021
1	Granzymes (Granzyme)IBA 12/2020
1	PerforinIBA 12/2020
1	Interleukin-9 (Interleukin 9)IBA 12/2020
1	pembrolizumabIBA 12/2020
1	Formaldehyde (Formol)FDA Link 11/2020
1	Everolimus FDA Link 10/2020
1	N-acetyl-tyrosyl-valyl-alanyl-aspartyl chloromethyl ketoneIBA 07/2020

Therapy/Procedure

7	Adjuvant Chemotherapy 09/2022 - 01/2017
7	Therapeutics 07/2022 - 08/2012
7	Immunotherapy 01/2022 - 04/2016
4	Drug Therapy (Chemotherapy) 12/2020 - 01/2012
3	Nephrectomy 03/2020 - 01/2016
2	Heart Transplantation (Grafting, Heart) 01/2020 - 01/2020
2	Pancreaticoduodenectomy 05/2018 - 08/2017
1	Radiotherapy 09/2021